:root{--bg: #080b11;--bg-2: #0b1019;--surface: #10161f;--surface-2: #151d29;--surface-3: #1c2634;--card: #121a24;--border: rgba(148, 163, 184, .13);--border-strong: rgba(148, 163, 184, .26);--text: #e8eef7;--muted: #98a6ba;--faint: #64748b;--teal: #2dd4bf;--violet: #a78bfa;--blue: #60a5fa;--amber: #fbbf24;--rose: #fb7185;--green: #34d399;--cyan: #22d3ee;--ax-target: #a78bfa;--ax-assay: #22d3ee;--ax-bioactivity: #38bdf8;--ax-admet: #2dd4bf;--ax-toxicity: #fb7185;--ax-ecotox: #34d399;--ax-physchem: #fbbf24;--ax-hazard: #f97316;--ax-compound: #94a3b8;--radius: 14px;--radius-sm: 9px;--shadow: 0 1px 2px rgba(0, 0, 0, .4), 0 8px 30px rgba(0, 0, 0, .35);--mono: ui-monospace, "SF Mono", "JetBrains Mono", "Cascadia Code", Menlo, Consolas, monospace;--sans: ui-sans-serif, system-ui, -apple-system, "Segoe UI", Roboto, "Helvetica Neue", Arial, sans-serif}*{box-sizing:border-box}html,body,#root{height:100%}body{margin:0;font-family:var(--sans);color:var(--text);background:radial-gradient(1200px 700px at 82% -10%,rgba(167,139,250,.1),transparent 60%),radial-gradient(1000px 600px at 8% 0%,rgba(45,212,191,.08),transparent 55%),var(--bg);-webkit-font-smoothing:antialiased;text-rendering:optimizeLegibility;font-feature-settings:"cv02","cv03","ss01";letter-spacing:-.01em}a{color:inherit;text-decoration:none}button{font:inherit;color:inherit;cursor:pointer}::selection{background:#2dd4bf47}.mono{font-family:var(--mono);font-variant-numeric:tabular-nums}html,body{overflow-x:hidden}.app{min-height:100%;max-width:100vw;display:flex;flex-direction:column}.topbar{position:sticky;top:0;z-index:30;display:flex;align-items:center;gap:22px;padding:13px 26px;background:#080b11b8;-webkit-backdrop-filter:saturate(140%) blur(14px);backdrop-filter:saturate(140%) blur(14px);border-bottom:1px solid var(--border)}.brand{display:flex;align-items:center;gap:11px;font-weight:640;letter-spacing:-.02em;font-size:16px}.brand .logo{width:30px;height:30px;display:grid;place-items:center;border-radius:9px;background:linear-gradient(140deg,var(--teal),var(--violet));color:#06121a;font-size:17px;box-shadow:0 4px 18px #2dd4bf59}.brand small{color:var(--faint);font-weight:500;font-size:11px;letter-spacing:.06em;text-transform:uppercase}.nav{display:flex;gap:4px;margin-left:8px}.nav a{padding:7px 13px;border-radius:9px;color:var(--muted);font-size:13.5px;font-weight:520;transition:background .15s,color .15s;white-space:nowrap}.nav a:hover{background:var(--surface-2);color:var(--text)}.nav a.active{color:var(--text);background:var(--surface-3);box-shadow:inset 0 0 0 1px var(--border-strong)}.topbar .spacer{flex:1}.mock-pill{font-size:11px;font-weight:600;letter-spacing:.04em;color:var(--amber);padding:5px 10px;border-radius:999px;background:#fbbf241a;border:1px solid rgba(251,191,36,.28)}.page{width:100%;max-width:1280px;margin:0 auto;padding:26px;flex:1}.page-wide{max-width:1480px}h1,h2,h3{margin:0;letter-spacing:-.025em}.h-hero{font-size:30px;font-weight:680}.h-sec{font-size:15px;font-weight:620;letter-spacing:.02em;text-transform:uppercase;color:var(--muted)}.sub{color:var(--muted);font-size:14px;line-height:1.55}.faint{color:var(--faint)}.search{display:flex;gap:10px;align-items:center}.search input{flex:1;background:var(--surface);border:1px solid var(--border-strong);color:var(--text);border-radius:12px;padding:14px 16px;font-size:15px;outline:none;transition:border .15s,box-shadow .15s;font-family:var(--mono)}.search input::placeholder{color:var(--faint);font-family:var(--sans)}.search input:focus{border-color:var(--teal);box-shadow:0 0 0 4px #2dd4bf21}.btn{border:1px solid var(--border-strong);background:var(--surface-2);border-radius:12px;padding:13px 20px;font-weight:580;font-size:14px;transition:transform .08s,background .15s,border .15s}.btn:hover{background:var(--surface-3)}.btn:active{transform:translateY(1px)}.btn-primary{background:linear-gradient(140deg,var(--teal),#14b8a6);color:#04121a;border:none;box-shadow:0 6px 20px #2dd4bf47}.btn-primary:hover{filter:brightness(1.05);background:linear-gradient(140deg,var(--teal),#14b8a6)}.btn-ghost{background:transparent}.chips{display:flex;flex-wrap:wrap;gap:7px}.chip{font-size:12.5px;padding:6px 11px;border-radius:999px;background:var(--surface-2);border:1px solid var(--border);color:var(--muted);transition:color .15s,border .15s,background .15s}.chip:hover{color:var(--text);border-color:var(--border-strong);background:var(--surface-3)}.card{background:var(--card);border:1px solid var(--border);border-radius:var(--radius);box-shadow:var(--shadow)}.pad{padding:18px}.mol-surface{background:linear-gradient(160deg,#fff,#f2f5f8);border-radius:var(--radius-sm);border:1px solid 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8px;border-radius:6px;text-transform:uppercase}.dot{width:8px;height:8px;border-radius:50%;display:inline-block}.grid{display:grid;gap:14px}.entity-grid{grid-template-columns:repeat(auto-fill,minmax(240px,1fr))}.mol-grid{grid-template-columns:repeat(auto-fill,minmax(210px,1fr))}.entity{background:var(--card);border:1px solid var(--border);border-radius:var(--radius-sm);padding:13px 14px;cursor:pointer;transition:transform .12s,border .15s,background .15s;position:relative;overflow:hidden}.entity:before{content:"";position:absolute;left:0;top:0;bottom:0;width:3px;background:var(--accent, var(--muted));opacity:.85}.entity:hover{transform:translateY(-2px);border-color:var(--border-strong);background:var(--surface-2)}.entity .name{font-size:13.5px;font-weight:570;line-height:1.3;margin-bottom:8px}.entity .val{font-family:var(--mono);font-size:18px;font-weight:600}.entity .row{display:flex;align-items:center;justify-content:space-between;gap:8px}.sec-head{display:flex;align-items:baseline;gap:10px;margin:26px 0 12px}.sec-head .count{font-family:var(--mono);font-size:12px;color:var(--faint)}.explorer{display:grid;grid-template-columns:340px 1fr;gap:22px;align-items:start}@media (max-width: 900px){.explorer{grid-template-columns:1fr}.nav{display:none}}.stat{display:flex;flex-direction:column;gap:3px}.stat .k{font-size:11px;text-transform:uppercase;letter-spacing:.05em;color:var(--faint)}.stat .v{font-family:var(--mono);font-size:15px;font-weight:600}.drawer-backdrop{position:fixed;top:0;right:0;bottom:0;left:0;background:#03060a9e;-webkit-backdrop-filter:blur(3px);backdrop-filter:blur(3px);z-index:40}.drawer{position:fixed;top:0;right:0;bottom:0;width:min(560px,92vw);background:var(--bg-2);border-left:1px solid var(--border-strong);z-index:50;overflow-y:auto;box-shadow:-20px 0 60px #00000080}.drawer 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.item{display:flex;align-items:center;gap:6px;font-size:12px;color:var(--muted)}.scroll-x{overflow-x:auto}.tick{color:var(--green)}.cross{color:var(--rose)}input[type=range]{accent-color:var(--teal)}select{background:var(--surface);color:var(--text);border:1px solid var(--border-strong);border-radius:9px;padding:8px 10px;font:inherit;outline:none}.opt{display:grid;grid-template-columns:250px minmax(0,1fr) 270px;gap:14px;height:calc(100vh - 92px);padding:8px 12px;box-sizing:border-box;width:100%}.opt-side,.opt-detail{background:var(--card);border:1px solid var(--border);border-radius:var(--radius);overflow-y:auto;overflow-x:hidden;padding:14px;min-width:0}.opt-graph-wrap{position:relative;min-width:0;background:radial-gradient(1200px 600px at 50% 40%,var(--bg-2),var(--bg));border:1px solid 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.opt-node-bg{fill:var(--surface-3)}.opt-node-delta{font-size:11px;font-weight:600;font-variant-numeric:tabular-nums}.opt-drug-star{fill:var(--amber);font-size:15px}.opt-node.drug circle:first-child{filter:drop-shadow(0 0 5px rgba(251,191,36,.5))}.opt-empty{color:var(--faint);text-align:center;margin-top:40px}.opt-detail-head{display:flex;justify-content:space-between;align-items:center;gap:8px}.opt-detail-kind{font-size:11px;text-transform:uppercase;letter-spacing:.06em;color:var(--muted)}.opt-drug-badge{font-size:11px;color:var(--amber);font-weight:600}.opt-detail-mol{background:var(--surface-2);border-radius:var(--radius-sm);padding:6px;margin:10px 0;display:flex;justify-content:center}.opt-detail-mol svg{max-width:100%;height:auto}.opt-drug-note{font-size:12px;color:var(--text);background:#fbbf2414;border:1px solid rgba(251,191,36,.25);border-radius:var(--radius-sm);padding:8px 10px}.opt-drug-note em{color:var(--muted)}.opt-edit{font-size:12px;color:var(--muted);margin:8px 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span{display:block;height:100%;border-radius:4px}.opt-expand-btn,.opt-run{width:100%;margin-top:12px;padding:9px;border-radius:var(--radius-sm);border:1px solid var(--border-strong);background:var(--surface-2);color:var(--text);cursor:pointer;font-size:12.5px}.opt-expand-btn:hover,.opt-run:hover{background:var(--surface-3)}.opt-run.primary{background:var(--teal);color:#05221f;border-color:var(--teal);font-weight:600}.opt-run:disabled{opacity:.5;cursor:default}.opt-tabs{display:flex;gap:4px;margin-bottom:12px}.opt-tabs button{flex:1;padding:7px;font-size:12px;border-radius:var(--radius-sm);border:1px solid var(--border);background:transparent;color:var(--muted);cursor:pointer}.opt-tabs button.on{background:var(--surface-2);color:var(--text);border-color:var(--border-strong)}.opt-examples{display:flex;flex-direction:column;gap:8px}.opt-ex{text-align:left;padding:10px;border-radius:var(--radius-sm);border:1px solid var(--border);background:var(--surface);cursor:pointer}.opt-ex:hover{border-color:var(--border-strong)}.opt-ex.on{border-color:var(--teal);background:var(--surface-2)}.opt-ex-title{font-size:13px;font-weight:600;color:var(--text)}.opt-ex-prompt{font-size:11.5px;color:var(--muted);font-style:italic;margin:3px 0}.opt-ex-meta{font-size:11px;color:var(--faint)}.opt-custom{display:flex;flex-direction:column;gap:6px}.opt-custom label{font-size:11px;color:var(--muted);margin-top:6px}.opt-custom input,.opt-custom textarea,.opt-obj select{width:100%;background:var(--surface-2);border:1px solid var(--border);border-radius:var(--radius-sm);color:var(--text);padding:7px;font-size:12px;font-family:inherit}.opt-objs{margin-top:10px;display:flex;flex-direction:column;gap:8px}.opt-obj{border:1px solid 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var(--teal);background:#2dd4bf1f;color:var(--teal);cursor:pointer;font-weight:600}.opt-chase:disabled{opacity:.5;cursor:default}.opt-reset{padding:6px 10px;font-size:11.5px;border-radius:var(--radius-sm);border:1px solid var(--border);background:var(--surface);color:var(--muted);cursor:pointer}.opt-detail-actions{display:flex;gap:6px;margin-top:12px}.opt-detail-actions .opt-expand-btn{margin-top:0;flex:1}.opt-hide-btn{padding:9px 10px;border-radius:var(--radius-sm);border:1px solid var(--border);background:transparent;color:var(--muted);cursor:pointer;font-size:12px}.opt-hide-btn:hover{border-color:var(--rose);color:var(--rose)}